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基于甘油三和葡萄糖的人类指数用于预测心血管疾病:相对脂肪质量 (RFM) 作为一个强大的指标
Xinlei Chu1, Haozhi Niu2, Ning Wang1
1School of Public Health, Nanjing Medical University, Nanjing 211166, China.
甘油三糖 (TyG) 指数与人体指标相结合,特别是相对脂肪量 (TyG-RFM),显示与心血管疾病 (CVD) 风险的关联比单独的TyG更强. 这种TyG-RFM指数可以改善心血管疾病风险分层,特别是在非肥胖个体中.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 公共卫生 公共卫生
背景情况:
- 甘油三糖 (TyG) 指数是与胰岛素抵抗相关的心血管疾病 (CVD) 风险的验证标志物.
- 将TyG指数与人类指标 (AI) 结合起来,可以提高心血管疾病风险预测.
- 当与TyG相结合时,各种AI的比较疗效,包括相对脂肪质量 (RFM),尚未得到充分确立.
研究的目的:
- 为了确定TyG指数和AI的哪个组合显示出最强烈的与事件心血管疾病的关联.
- 为了比较复合TyG-AI指数对心血管疾病,心脏病和中风的预测值.
- 评估新型指数如TyG-RFM在心血管风险评估中的有用性.
主要方法:
- 一项前性研究利用了中国健康与退休长度研究 (CHARLS) 中5192名参与者的数据.
- 评估Tyg与八种AIs (TyG-AIs) 结合的累积平均值与发生的心血管疾病,心脏病和中风之间的关联.
- 应用多变量逻辑回归来比较不同TyG-AI复合指数的预测性能.
主要成果:
- 在随访期间,1382名 (26.6%) 参与者患有心血管疾病.
- 单独的TyG指数在完全调整后仅与中风有显著关联.
- 大多数TyG-AI组合与所有心脏病结局的关联更强;TyG-RFM与总心脏病,心脏病和中风的关联最强.
结论:
- 累计平均TyG-AIs,特别是TyG-RFM指数,与单独的TyG指数相比,与事件心血管疾病有更强大的关联.
- 泰格-RFM指数显示出作为改善心血管风险分层的工具的巨大潜力.
- 这一指数对于识别不被归类为肥胖的有风险个体可能特别有价值.
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