饮食中氨基酸摄入量与儿童高敏感性C反应性蛋白之间的关联:来自跨部分机器学习研究的见解
Lianlong Yu1,2, Xiaodong Zheng1, Jilan Li1
1Jinan Fruit Research Institute, All-China Federation of Supply and Marketing Co-Operatives, Jinan 250014, China.
Nutrients
|July 12, 2025
概括
饮食中的氨基酸摄入量,特别是氨酸,氨酸,氨酸和氨酸,与儿童炎症标志物 (hs-CRP) 的升高有关. 了解这些联系可以为预防与炎症相关的疾病的策略提供信息.
科学领域:
- 营养科学 营养科学
- 儿科健康 儿科健康
- 生物化学 生物化学
背景情况:
- 高灵敏度C反应蛋白 (hs-CRP) 是炎症和心血管疾病风险的关键指标.
- 饮食中的氨基酸可以调节免疫和炎症反应.
- 在儿童群体中,饮食氨基酸和hs-CRP之间的关联存在有限的研究.
研究的目的:
- 调查各种食氨基酸摄入量与儿童hs-CRP水平升高之间的关系.
- 确定与儿科患者炎症风险增加相关的特定氨基酸.
- 探索机器学习在基于氨基酸摄入量的hs-CRP水平预测中的实用性.
主要方法:
- 来自中国儿童和哺乳妇女营养和健康调查 (2016-2019) 的3514名儿童的横截面分析.
- 通过食物频率问卷评估饮食摄入量;hs-CRP从血液样本中测量.
- 机器学习 (LightGBM) 和逻辑回归模型,Boruta算法和倾向得分匹配,被用来分析关联.
主要成果:
- 在升高的hs-CRP与摄入Ile,Leu,Lys,Ser,Cys,Tyr,His,Pro,SAA和AAA之间发现了显著的积极关联 (ORs 1.10-2.07).
- 在LightGBM模型中,对于高hs-CRP风险 (AUC=0.927) 的预测准确度很高.
- 铁,氨酸,氨酸和氨酸被确定为关键预测因子;它们的摄入量显示hs-CRP风险的线性增加,特别是在正常体重的儿童中,蛋白质摄入量低.
结论:
- 特定的氨基酸 (Ser,Cys,Tyr,Pro) 显著影响儿童的hs-CRP水平.
- 调节这些氨基酸的摄入量可能是预防儿童炎症相关疾病的策略.
- 这项研究使用中国的大规模ML分析对儿科炎症提供了新的见解,突出了饮食管理潜力.
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