对于25-氧维生素D的血清度的最小显著变化 (LSC)
Pawel Pludowski1, Marek Wójcik1, Maciej Jaworski1
1Department of Clinical Biochemistry, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Nutrients
|July 12, 2025
概括
最不显著的变化 (LSC) 方法有助于确定25-基维生素D [25(OH) D]水平中最小的重要差异. 对于IDS-iSYS试验,确定了4.0 ng/mL的LSC,根据维生素D状态而有所不同.
科学领域:
- 临床化学 临床化学
- 实验室医学 实验室医学
- 内分泌学 在内分泌学.
背景情况:
- 最不显著的变化 (LSC) 对于定义连续测量之间的最小临床重要差异至关重要.
- 准确地解释序列25-基维生素D[25(OH) D]测量需要了解测试的可变性.
研究的目的:
- 为了确定和验证IDS-iSYS测定测量25-氧维生素D[25(OH) D]的最小显著变化 (LSC).
- 评估患者人口统计和维生素D状态对LSC的影响.
主要方法:
- 使用根平均平方精度误差乘以2.77乘以2.77计算LSC.
- 分析了150名患者的450个三重复制的25(OH) D IDS-iSYS测定.
- 按性别,年龄,25...OH) D度和测定日期进行分层分析.
主要成果:
- 整体LSC为4.0 ng/mL (13.2%),不依据性别,年龄或检测日期.
- 在25(OH) D度下,LSC显著变化:2.2 ng/mL (<20 ng/mL) 和11.8 ng/mL (>50 ng/mL).
- 与其他组相比,在维生素D缺乏症 (<20 ng/mL) 中观察到较低的LSC.
结论:
- 对于IDS-iSYS 25(OH) D试验,确定了4.0 ng/mL的绝对LSC.
- LSC是度依赖的,特别是在维生素D缺乏的情况下更低.
- 这种LSC值对于在临床实践中解释序列25(OH) D结果至关重要.
相关概念视频
01:23Role of Skin in Vitamin D Synthesis
5.7K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.7K
01:21Skeleton and Calcium Homeostasis
4.8K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.8K
01:14Time Course of Drug Effect
2.2K
The progression of a drug's impact can be analyzed by examining both the concentration-time course and the effect-time course. The concentration-time course is determined by the drug's half-life and is influenced by factors such as its pharmacokinetics, including absorption, distribution, metabolism, and elimination. The effect of the drug is often related to its concentration in the plasma and is calculated using the maximum drug effect and the plasma concentration that generates 50...
2.2K
01:25Role of Vitamins in Maintaining Bone Health
3.7K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.7K
01:17Hormones and Bone Tissue
2.9K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.9K
01:24Serum Studies: Renal Function Tests
48
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
48