对于膀癌的新策略和治疗进展
Matthew I Ehrlich1, Robert D Fox1, Karie D Runcie1
1Division of Hematology & Oncology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Cancers
|July 12, 2025
概括
新型治疗方法正在迅速改变膀癌的治疗方法. 研究重点是肌肉侵入性膀癌 (MIBC) 的膀节省选择以及转移性疾病的先进疗法.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 膀癌治疗已经取得了重大进展.
- 对于膀癌的不同阶段,新的治疗策略正在出现.
研究的目的:
- 审查最近的临床试验和膀癌治疗的治疗进展.
- 概括了膀癌治疗中的新策略和正在进行的研究.
主要方法:
- 对最近和正在进行的临床试验 (2020年以后) 的综合文献综述.
- 专注于治疗膀癌的新疗法和治疗策略.
主要成果:
- 对于肌肉侵入性膀癌 (MIBC),新辅助化疗与外科期免疫疗法是适合西斯普拉丁治疗的患者的标准;对于不适合西斯普拉丁治疗的患者缺乏指导方针.
- 针对MIBC的研究策略包括化疗,免疫疗法,辐射,抗体-药物合物 (ADC),向药物,静脉内治疗和个性化疫苗的组合,正在研究节约膀的方法.
- 在高级/转移性病例中,恩福图马布维多丁加上布罗利祖马布现在是第一线治疗,取代了基于的化疗. 进展的研究选择包括新的免疫疗法,ADC,小分子抑制剂和细胞疗法.
结论:
- 最近,膀癌的治疗场景发生了巨大的变化.
- 目前正在进行的试验旨在建立MIBC的膀节约方法和晚期疾病的新系统疗法.
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