在炎症性肠病和原发性硬化胆管炎中导航瘤风险
Demis Pitoni1,2, Arianna Dal Buono1,3, Roberto Gabbiadini1
1IBD Center, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Cancers
|July 12, 2025
概括
患有炎症性肠病 (IBD) 和原发性硬化性胆管炎 (PSC) 的患者患有结直肠癌 (CRC) 和胆管癌 (CCA) 的风险较高. 早期检测和先进的预防策略对于管理这一群体的癌症风险至关重要.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 在瘤学瘤学.
背景情况:
- 患有炎症性肠病 (IBD) 和原发性硬化性胆道炎 (PSC) 的患者显着增加结直肠癌 (CRC) 和胆管癌 (CCA) 的风险.
- 导致PSC-IBD患者癌症风险增加的精确分子机制尚未完全阐明.
- 本综述综合了有关癌症发展,诊断和预防的当前知识,在这个特定的患者队列.
研究的目的:
- 审查和整合最近关于原发性硬化胆管炎和炎症性肠病 (PSC-IBD) 患者癌症风险的研究结果.
- 专注于分子途径,诊断创新和预防策略,这些都与此种人群中的结直肠癌 (CRC) 和胆管癌 (CCA) 有关.
主要方法:
- 在PubMed进行了系统的文献搜索,截至2025年3月.
- 包括专注于瘤性过程,分子机制以及PSC-IBD患者CRC和CCA诊断和预防策略的进展的研究.
主要成果:
- 目前的监测包括每年对CRC进行结肠镜检查和对CCA进行CA 19-9监测的成像检查.
- 新兴研究表明,PSC-IBD的瘤发生过程中存在分子变化,例如表观遗传修饰.
- 分子诊断,成像和内镜技术的创新提高了癌症检测的准确性和效率.
结论:
- 患有PSC-IBD的人面临CRC和CCA的持续高风险,这强调了严格监测和积极预防的必要性.
- 早期检测和精确诊断方面的进步为减轻这一弱势群体癌症负担提供了重大机会.
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