由牙周炎引起的口腔微生物失生症促进了口腔状细胞癌的进展
Qing Yuan1, Hao Wu1, Hanyue Tan1
1Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Tianjin Medical University, 12 Qi Xiang Tai Road, Heping District, Tianjin 300070, China.
Cancers
|July 12, 2025
概括
牙周炎通过改变口腔微生物群和增加炎症来促进口腔癌 (OSCC) 的生长和入侵. 保持牙周健康对于OSCC的预防和管理至关重要.
科学领域:
- 口腔瘤学 在口腔瘤学
- 微生物学 微生物学
- 炎症研究的研究.
背景情况:
- 口腔状细胞癌 (OSCC) 是一个严重的全球健康问题,预后不佳.
- 牙周炎是一种慢性炎症性疾病,越来越多地与癌症的发展有关.
- 口腔微生物失生症可能会创造一种支持瘤的环境,但机制尚不清楚.
研究的目的:
- 调查牙周炎和OSCC进展之间的关联.
- 阐明口腔微生物群失生症在调解这种关系中的作用.
- 分析牙周炎对OSCC细胞增殖和侵入的影响.
主要方法:
- 在小鼠中确立的带诱导性牙周炎和SCC-7细胞诱导的OSCC模型.
- 使用CCK-8和伤愈合试验评估了OSCC细胞的增殖和入侵.
- 使用16SrDNA测序分析了口腔和瘤微生物群,并通过qPCR量化了细胞因子表达 (IL-1β,IL-10,IL-18).
主要成果:
- 牙周炎显著促进了OSCC的生长和入侵.
- 微生物分析显示,口腔和OSCC微生物群的组成和多样性发生了显著变化.
- 在牙周和OSCC组织中IL-1β,IL-10和IL-18表达的增加表明炎症加剧.
结论:
- 牙周炎引起的微生物失生症和炎症协同驱动OSCC的进展.
- 一个促炎性瘤微环境调解了牙周炎和OSCC之间的相互作用.
- 保持牙周健康对于OSCC的预防和管理至关重要.
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