脑膜炎/血清病的分子鉴定 由于菌菌 spp. 在希腊 (2015-2024) 期间
Constantinos Karamalis1, Athanasia Xirogianni1, Stelmos Simantirakis1
1National Meningitis Reference Laboratory, Department of Public Health Policy, School of Public Health, University of West Attica, 1152 Athens, Greece.
Diagnostics (Basel, Switzerland)
|July 12, 2025
概括
分子诊断确定了在希腊引起脑膜炎的链球菌种. 这项研究发现,虫和发炎组是最常见的,儿童和老年人患病率更高.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 分子诊断学 分子诊断
背景情况:
- 由Streptococcus物种引起的脑膜炎是一种严重的中枢神经系统感染.
- 准确识别流球菌物种对于有效的临床管理至关重要.
- 关于在希腊引起脑膜炎的特定菌株菌株菌株的数据有限.
研究的目的:
- 在9年的时间里,在希腊发现导致脑膜炎的菌株.
- 用分子诊断技术来准确识别物种.
- 分析流行病学趋势和与年龄有关的易感性.
主要方法:
- 分析了来自脑膜炎和/或败血症患者的189个临床样本 (2015-2024年).
- 多重聚合酶连锁反应 (PCR) 试验的应用.
- 利用图夫基因测序进行进一步的物种识别.
主要成果:
- 杆菌 pyogenes (A组杆菌) 和杆菌 agalactiae (B组杆菌) 每一个占确诊病例的18.52%.
- 非类型化的链球菌种占样本的62.96%.
- 虫群 (42.86%) 和热性群 (20.17%) 是通过测序识别的最常见的链球菌种.
- 在儿童 (0-14岁) 和50岁以上成年人中观察到更高的患病率.
结论:
- 分子诊断在识别导致脑膜炎的多种类型的菌株中是有效的.
- 这项研究提供了关于希腊链球菌脑膜炎流行病学的见解.
- 确定了与年龄相关的敏感性模式,需要进一步调查,包括乳球菌种的作用.
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