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在孕前中,全身和局部免疫学标记

Almagul Kurmanova¹, Altynay Nurmakova^2,3, Damilya Salimbayeva^2,3

¹Department of Obstetrics and Gynecology, Al-Farabi Kazakh National University, 71 Al-Farabi Ave., 050040 Almaty, Kazakhstan.

Diagnostics (Basel, Switzerland)

|July 12, 2025

概括

孕前症涉及到母体血液和胎盘的免疫系统变化. 免疫细胞如T,B和NK细胞的失调有助于炎症和氧化应激,影响怀孕的结果.

科学领域:

免疫学免疫学免疫学
产科产科产科产科产科
周围生理学周围生理学

背景情况:

孕前 (PE) 是孕产妇和新生儿死亡的主要原因之一.
母亲的免疫系统平衡了病原体防御和对半异性胎儿的耐受性.
免疫调节障碍与PE病变发生有关.

研究的目的:

为了比较母体血液和胎盘中的免疫标志物,在子宫前和正常怀孕之间.
为了研究免疫细胞亚群和细胞因子概况.

主要方法:

对35名孕妇进行的比较研究 (7名孕妇,28名对照).
周围血液和胎盘组织的流细胞计分析.
对淋巴细胞亚种群和细胞内细胞因子生产的评估.

主要成果:

在PE血液中,CD14+单细胞减少,NK细胞增加 (CD16+,CD56+) 和激活标志物 (HLA-DR+,CD95+) 增加.
在PE血液中发现IL-10,TNF,Perforin,GM-CSF和IGF的升高.
在PE胎盘中,调控细胞 (CD4+,CD8+,CD14+,CD56+,CD59+),激活标志物 (CD95+),IL-10,VEGFR和IGF的减少.

结论:

母胎免疫特征对胎儿发育至关重要.
T,B和NK细胞的失调有助于炎症,氧化应激和孕前的发展.

关键词:

细胞因子细胞因子免疫系统免疫系统孕产妇医学孕产妇医学胎盘胎盘胎盘胎盘孕产妇产前炎症 (pre-eclampsia) 是一个严重的疾病.

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