与向疗法和生物药物相关的药物诱导的类反应
Federica Andolfi1, Luca Caffarri1, Matilde Neviani1
1Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41121 Modena, Italy.
药物诱导的类反应 (DISR) 模仿类病,通常是由向治疗引起的. 结构化诊断方法和个性化管理,包括药物停用,是患者护理的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 皮肤病学 皮肤病学
背景情况:
- Sarcoidosis 是一种多系统炎症性疾病,其特征是颗粒瘤.
- 药物诱导的类反应 (DISRs) 模仿类病,越来越多地与向治疗有关.
- DISRs由于它们与肉类突发症的相似性而构成诊断挑战.
研究的目的:
- 审查和综合有关药物诱导的类反应的当前知识.
- 确定与DISRs相关的药理学类.
- 为可疑的DISRs提出一个诊断算法.
主要方法:
- 对PubMed文献进行叙述性审查,使用诸如"SARCOID LIKE REACTION"和"Drug"等术语.
- 与"SARCOID"和特定药物进行交叉检查,以确定错误分类的病例.
- 基于病例报告,系列和评论,包括具有强烈病原学可信性的分子向疗法.
主要成果:
- 确定了与DISR相关的五个主要药理学组:免疫检查点抑制剂,TNF-α对抗剂,BRAF抑制剂,单克隆抗体和各种药物.
- 截然不同的作用机制和临床指示影响了DISR的频率,表现和时间.
- 停止使用致病药物往往是有效的管理DISRs.
结论:
- 诊断DISR需要一种结构化的方法来区分其与其他疾病.
- 一个拟议的诊断算法有助于临床医生管理疑似DISR.
- 考虑到疾病严重程度,替代方案和DISR程度的个性化管理至关重要.
更多相关视频
06:08Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
相关概念视频
Allergic Drug Reactions
Targeted Cancer Therapies
There are several types of targeted therapies against...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)