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用奇多/阿拉伯纳米颗粒用于局部护肤应用的瑞加载皮克林乳液的配方和稳定性

Mathukorn Sainakham¹, Paemika Arunlakvilart¹, Napatwan Samran¹

¹Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

|July 12, 2025

概括

奇托/阿拉伯纳米颗粒稳定了含有素的皮克林乳液,保持了抗氧化活性,并保护细胞免受氧化应激. 这种天然聚合物系统增强了奎尔塞丁.

科学领域:

材料科学:开发基于天然聚合物的新型纳米颗粒用于乳液稳定.
食品科学与技术:使用皮克林乳液来增强生物活性化合物的输送.
生物化学:对封装Quercetin的抗氧化活性和稳定性的研究.

背景情况:

自然聚合物纳米颗粒为皮克林乳液稳定提供了可持续和生物相容的替代品.
奎尔是一种强大的抗氧化剂,由于氧化降解,其稳定性受到限制.
由纳米颗粒稳定的皮克林乳液可以保护活性化合物并提高其生物可用性.

研究的目的:

开发基托桑/阿拉伯 (CH/GA) 纳米颗粒作为素加载皮克林乳液的稳定剂.
为了增强奎尔丁 (QE) 的稳定性和抗氧化生物活性.
评估影响乳液稳定性和输送系统性能的配方参数.

主要方法:

系统的CH/GA纳米颗粒和皮克林乳液的配方,具有不同的CH/GA度,油类型和油体积分数.
使用HPLC对乳液稳定性,颗粒大小,滴滴形态,形学和氨酸保留的表征.
在HaCaT角质细胞中评估抗氧化活性 (DPPH测定) 和细胞相容性/ROS保护.

主要成果:

最佳的乳液稳定性是在1.5%CH/GA和橄油在0.6油体积分数下实现的.
带素的乳液 (D1-QE) 显示出高稳定性,在室温下保持92.8%的QE,在30天后在加速条件下保持82.8%.
乳液表现出保存的抗氧化活性和显著降低内ROS在角质细胞,没有观察到细胞毒性.

结论:

CH/GA纳米颗粒有效地稳定素加载的皮克林乳液,提供强大的界面屏障.
开发的系统显著提高了奎尔素的稳定性,并保留了其抗氧化功能.
这些发现凸显了CH/GA稳定皮克林乳液作为生物活性化合物的有前途的输送系统的潜力.

关键词:

抗氧化剂稳定性抗氧化剂稳定性生物聚合物稳定剂生物聚合物稳定剂基多酸盐的使用方法乳液的稳定性乳液的稳定性封装的封装方式阿拉伯口香糖的阿拉伯语皮克林的乳液是什么意思文素 (Quercetin) 是一种文素.

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