在Hydra vulgaris暴露于聚乙烯和聚烯纳米颗粒的次致命毒性和基因表达变化
Joelle Auclair1, Chantale André1, François Gagné1
1Environment and Climate Change Canada, Aquatic Contaminants Research Division, Montréal, QC H2Y 2E7, Canada.
Nanomaterials (Basel, Switzerland)
|July 12, 2025
概括
聚烯和聚乙烯纳米塑料对水生生物产生影响,即使在低度也会影响基因表达. 聚烯纳米塑料显示出更大的毒性,导致形态变化,与聚乙烯纳米塑料不同.
科学领域:
- 环境毒理学环境毒理学
- 生态毒理学 生态毒理学
- 纳米毒理学研究
背景情况:
- 塑料降解中的塑料纳米颗粒 (NP) 在水生环境中普遍存在.
- 有关这些NP对水生生物的长期毒性影响存在担忧.
研究的目的:
- 为了研究Hydra vulgaris中聚乙烯 (PeNPs) 和聚烯 (PpNPs) 纳米粒子的亚致命毒性.
- 为了比较同样大小 (50 nm) 的PeNPs和PpNPs对Hydra vulgaris的影响.
主要方法:
- 在20°C下,Hydra vulgaris被暴露在不同度 (0.3-10 mg/L) 的PeNPs和PpNPs中,持续96小时.
- 毒性评估涉及观察形态变化和分析与氧化应激,DNA修复,蛋白质代谢,神经活动和再生相关的基因表达.
主要成果:
- 聚烯纳米塑料 (PpNPs) 诱导了形态变化 (EC50 = 7 mg/L),而聚乙烯纳米塑料 (PeNPs) 没有.
- 在0.3 mg/L以下的度下,PeNPs和PpNPs都在所有目标中改变了基因表达.
- PpNP通常表现出比PeNP更强烈的毒性作用,在氧化应激,DNA修复,再生和昼夜节律路径中观察到不同的作用模式.
结论:
- 无论是PeNPs还是PpNPs,在环境相关的度下,都会产生生物效应,低于可见形态损害的值.
- 纳米塑料对水生生物构成重大风险,影响基本的生物过程.
- 该研究强调了纳米级塑料聚合物类型之间的差异性毒性.
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