在使用金属/氧化金属纳米颗粒,抗生素和植物化学品的抗菌表面涂料方面的进展
Preetha Ebenezer1,2, S P S N Buddhika Sampath Kumara1,2,3, S W M A Ishantha Senevirathne1,2,3
1School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia.
Nanomaterials (Basel, Switzerland)
|July 12, 2025
概括
由于细菌感染和抗菌素耐药性 (AMR) 的增加,医疗植入物的创新抗菌涂层至关重要. 本综述探讨了金属/金属氧化物纳米粒子,抗生素和植物化学品,以提高植入物生物相容性和抗菌活性.
科学领域:
- 生物材料科学 生物材料科学
- 传染病研究 传染病研究
- 纳米技术 纳米技术
背景情况:
- 越来越多的细菌感染和抗微生物耐药性 (AMR) 需要为医疗植入物提供先进的抗微生物涂层.
- 植入物表面的特性极大地影响生物相容性,耐腐蚀性和抗菌功效.
- 目前的策略面临挑战,包括耐药性,细胞毒性和有限的有效性.
研究的目的:
- 审查和评估用于医疗植入物表面功能化的三大类抗菌剂.
- 为了比较金属/金属氧化物纳米粒子,抗生素和植物化学品的疗效,机制和局限性.
- 突出下一代涂料在改善感染控制和组织再生方面的潜力.
主要方法:
- 在植入物表面功能化中使用的抗菌剂的文献综述.
- 分析金属/金属氧化物纳米粒子 (Ag,ZnO,CuO) 用于抗菌机制.
- 对抗生素和植物化学物质 (库尔库明,尤根醇,奎尔) 涂料的有效性和生物相容性进行评估.
主要成果:
- 金属/金属氧化物纳米颗粒通过ROS生成和膜破坏提供了宽频活性,降低了通过ROS产生和膜破坏的阻力风险.
- 抗生素涂层提供局部传递,但遭受爆发释放,细胞毒性和减少对抗多药耐药 (MDR) 菌株的有效性.
- 植物化学涂料显示出有希望的生物相容性,可持续的替代品,具有抗微生物,抗炎,抗氧化和骨质效应的好处.
结论:
- 金属/金属氧化物纳米粒子,抗生素和植物化学品是开发有效的抗菌植入物涂层的关键策略.
- 植物化学品具有多功能优势,包括生物相容性和再生潜力.
- 这些剂在下一代涂料中的协同应用可以显著提高植入物治疗的感染控制和临床结果.
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