在角膜折射手术后,慢性神经病性眼痛和干眼的长期演变
Cristina Valencia-Sandonís1, Amanda Vázquez1,2, Laura Valencia-Nieto1
1Institute of Applied Ophthalmobiology (IOBA), Universidad de Valladolid (UVa), Campus Miguel Delibes, Paseo de Belén 17, 47011 Valladolid, Spain.
Journal of clinical medicine
|July 12, 2025
概括
经过折射手术后,神经病态眼部疼痛和干眼症状得到改善,但眼生物标志物表明正在进行的神经炎症和抗炎症反应. 这表明手术后复杂的愈合动态.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 慢性神经病性眼部疼痛 (NOP) 和干眼 (DE) 是低诊断的眼部手术后并发症.
- 这项研究调查了角膜折射手术 (RS) 后NOP和DE的长期进展.
研究的目的:
- 为了评估症状的长期演变,临床征兆和眼生物标志物在经历了角膜RS后NOP和DE的患者.
- 了解慢性眼睛疼痛和炎症后折射手术的潜在机制.
主要方法:
- 在至少两年内对23名患有NOP和DE的角膜后RS患者进行前性评估.
- 评估症状 (DE,疼痛,焦虑,抑郁) 通过问卷,临床检查 (眼睛表面,角膜敏感性,神经) 和眼生物标志物分析 (细胞因子,物质P).
主要成果:
- 显著改善ED症状,焦虑和抑郁,同时减少角膜染色.
- 角膜神经的参数和灵敏度保持不变.
- 观察到高度的碎素/CX3CL1,IL-1受体对抗剂 (IL-1Ra),IL-10和物质P (SP).
结论:
- 虽然DE症状和心理困扰在折射手术后得到改善,但高SP和碎素表明持续的神经性炎症.
- 增加的IL-1Ra和IL-10表明同时存在抗炎反应.
- 这些发现突出了炎症和治疗在手术后的慢性眼痛中复杂的相互作用.
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