血红蛋白与红细胞分布宽度比率与心血管疾病和死亡有关
Mengyi Li1,2, Hanbin Li1,2, Wen Zhong1,2
1Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Journal of clinical medicine
|July 12, 2025
概括
血红蛋白与红细胞分布宽度比 (HRR) 与心血管疾病 (CVD) 和死亡风险降低有关. 较高的HRR水平表明风险降低,中度水平显示冠心病风险最低.
科学领域:
- 心血管医学 心血管医学
- 血液学 血液学 血液学
- 生物标志物 生物标志物
背景情况:
- 血红蛋白与红细胞分布宽度比 (HRR) 是一个反映炎症和氧化应激的新兴生物标志物.
- 以前的研究表明HRR与心血管疾病 (CVD) 之间存在联系,但关于特定事件和死亡率的证据有限.
研究的目的:
- 调查HRR与各种心血管事件发生率和全因死亡率之间的关联.
- 为了评估HRR的预测性能,与单独的血红蛋白和红细胞分布宽度 (RDW) 相比.
主要方法:
- 分析了国家健康和营养检查调查 (NHANES) (1999-2018) 中47719名参与者的数据.
- HRR计算为血红蛋白除以RDW. HRR计算为血红蛋白除以RDW.
- 多变量分析和受限立方脊柱曲线用于评估与心血管疾病 (包括中风,心力衰竭,ASCVD,冠状动脉疾病) 和死亡率的关联.
主要成果:
- 较高的HRR水平与心血管疾病,中风,心力衰竭和动脉样硬化心血管疾病 (ASCVD) 的风险降低显著相关.
- 中度HRR水平 (Q3) 显示冠心病的风险最低.
- HRR显示出所有原因,心血管和非心血管死亡的显著预测能力,优于个体血红蛋白和RDW测量.
结论:
- 升高的HRR与心血管疾病和死亡率降低的风险有关.
- HRR是预测心血管事件和整体死亡率的有价值生物标志物.
- 与其组成部分相比,HRR在预测所有原因死亡方面表现出优越的辨别能力.
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