角膜交叉连接对内皮和生机学参数在角质的影响
Maria-Silvia Dina1, Maria-Cristina Marinescu1, Cătălina-Gabriela Corbu2
1Doctoral School, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Journal of clinical medicine
|July 12, 2025
概括
角膜原交联 (CXL) 有效地阻止了角质的进展. 晚期角膜的阶段显示出角膜生物力学和内皮细胞变化的改变,CXL后有轻微的内皮效应.
科学领域:
- 眼科医生 眼科 眼科
- 角质细胞疾病 角质细胞疾病
- 生物材料科学是生物材料的科学.
背景情况:
- 角膜 (KC) 是一种渐进的角膜脱落性疾病,由于稀薄,近视和形导致视力丧失.
- 角膜原交联 (CXL) 是阻止KC进展的关键治疗方法.
研究的目的:
- 为了评估角膜内皮和生物机械性质在角质患者.
- 为了评估前后的变化,前后的Epi-off角膜原交联 (CXL).
主要方法:
- 66个眼睛有进展性角质,经历了CXL.
- 术前和术后的评估包括角膜拓,镜面显微镜 (内皮参数) 和眼睛反应分析仪 (生物力学参数).
- 测量是在基线,CXL后1个月和6个月进行的.
主要成果:
- 先进的KC阶段与更高的内皮细胞变异性,较低的近中心细胞数量,减少的角膜歇斯底里症 (CH) 和角膜抵抗因子 (CRF),以及增加的角质测量和形.
- 内皮细胞的变异性和数量与平均角质量相关;地形与CH和CRF有很强的相关性.
- 在CXL后,对中心内皮细胞数量减少,而细胞变异性和平均细胞表面积增加.
结论:
- 晚期角膜显著改变角膜生物力学和地形,对角膜内皮有相应的影响.
- 间歇性CXL对角膜内皮表现出轻微的影响,同时对角质进展的治疗效益.
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