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在脊椎关节炎患者中未被诊断的炎症性肠病的患病率
Jesús Sanz-Sanz1, Ana Gutiérrez-Casbas2, Zulema Plaza3
1Departamento de Reumatología, Hospital Universitario Puerta de Hierro, Majadahonda, 28222 Madrid, Spain.
Journal of clinical medicine
|July 12, 2025
概括
在脊椎关节炎 (SpA) 患者中未诊断的炎症性肠病 (IBD) 的患病率为5.7%,在轴性SpA中高于牛皮性关节炎. 便中calprotectin水平低于147μg/g表明SPA患者IBD的概率很低.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD) 和脊椎关节炎 (SpA) 具有重叠的临床和遗传特征.
- 在SPA患者中未被诊断的IBD的患病率仍然在很大程度上是未知的.
研究的目的:
- 确定SPA患者未诊断的IBD的患病率,包括轴性SPA (axSpA) 和牛皮关节炎 (PsA).
- 评估便calprotectin (FC) 水平的诊断准确性,以确定该人群中的IBD.
主要方法:
- 这是一项跨截面,多中心,观察性研究 (EISER),涉及风湿病学家和胃肠道学家的合作.
- 招募以前没有使用过生物药物的SPA患者,收集人口统计,临床和治疗数据.
- 通过结肠镜或视频囊内镜检查患有高FC (≥80μg/g) 或IBD症状的患者的检查;用于FC预测值的ROC分析.
主要成果:
- 在494名可评估的SPA患者中,5.7%被诊断患有IBD.
- 与PsA (2.4%) 相比,axSpA (8.9%) 的IBD患病率更高.
- 克罗恩氏病 (CD) 是最常见的IBD亚型 (86%的确诊IBD病例). 一个FC水平≥147μg/g显示IBD的积极预测值为17.4%.
结论:
- 未诊断的IBD影响5.7%的SpA患者,axSpA的患病率明显高于PsA.
- 克罗恩氏病是这一群体中占主导地位的IBD形式.
- 具有FC水平低于147μg/g的SpA患者患IBD的可能性很小.
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