第4天与第5天新鲜胚胎转移在体外受精:这一切都是关于时间吗?
Alper Şişmanoğlu1, Süleyman Cemil Oğlak2, Cenk Özcan3
1Department of Obstetrics and Gynecology, Altınbaş University Faculty of Medicine, 34147 Istanbul, Türkiye.
Journal of clinical medicine
|July 12, 2025
概括
与第4天移植相比,在第5天的新鲜胚胎移植显著增加了怀孕成功率. 建议在第五天进行转移,特别是40岁以上的女性,以优化体外受精结果.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 在体外受精过程中受精.
背景情况:
- 大多数体外受精 (IVF) 研究将分裂阶段与胚芽细胞阶段的胚胎进行比较.
- 在对抗剂调节的试管婴儿周期内,在第4天和第5天新鲜胚胎移植之间比较怀孕率的研究有限.
研究的目的:
- 为了比较第四天和第五天新鲜胚胎移植之间的怀孕率.
- 为了确定影响新鲜,对手调节的试管婴儿周期中怀孕成功的因素.
主要方法:
- 对3681个新鲜胚胎移植周期 (2019-2021) 的回顾性队列研究.
- 患者分为第4天 (第一组) 和第5天 (第二组) 的转移组.
- 基于患者年龄和卵细胞检索数量的子组分析;使用GnRH抗剂协议.
主要成果:
- 在第5天的转移中,与第4天的转移 (54.2%) 相比,妊娠率更高 (65.3%).
- 在第五天的单个胚胎移植增加了1.8倍的妊娠成功率;双个胚胎移植增加了1.6倍.
- 第5天移植显示,无论年龄,卵细胞数或胚胎数量,怀孕成功率增加了1.9倍.
结论:
- 第五天的新鲜胚胎移植优于第四天的移植,改善了怀孕率.
- 应优先考虑5日转移,特别是40岁以上的女性,以提高试管婴儿的成功率.
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