慢性饮酒对老年人认知功能的影响
Simona-Dana Mitincu-Caramfil1, Alina Plesea-Condratovici2, Alexia Anastasia Stefania Balta2,3
1Department of Pharmaceutical Sciences, Dunărea de Jos University, 800008 Galati, Romania.
Journal of clinical medicine
|July 12, 2025
概括
慢性饮酒的老年人认知障碍很常见,特别是在罗马尼亚农村地区. 肝功能障碍有助于认知能力下降,但在住院治疗后可能有所改善.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 慢性饮酒会显著影响老年人的认知功能.
- 罗马尼亚的城乡差异加剧了与酒精有关的认知缺陷的问题.
- 可逆性肝功能障碍在认知表现中的作用需要进一步研究.
研究的目的:
- 在慢性饮酒的老年患者中使用迷你精神状态检查 (MMSE) 评估认知功能.
- 为了确定农村和城市人口之间的认知功能的差异.
- 分析肝脏标志物和MMSE得分之间的关系.
主要方法:
- 一项对152名因酒精戒断而住院的55岁以上患者进行的回顾性观察性研究.
- 收集人口统计数据,MMSE分数 (入院和出院),以及肝脏参数 (AST,ALT,GGT,总 bilirubin,氨).
- 统计分析包括描述性统计,千二测试,配对t测试/ANOVA和皮尔森相关性.
主要成果:
- 94%的患者在入院时MMSE得分低于24分.
- 住院后的MMSE平均得分从23.4提高到25.0 (p < 0.001).
- 与城市患者 (24.8) 相比,农村患者的入院MMSE得分 (22.6) 较低 (p = 0.02),在出院时的差距仍然存在.
- 高的玛-氨基转移酶 (GGT) 水平与MMSE得分呈反向相关性 (r = -0.41; p < 0.001).
结论:
- 与酒精有关的认知障碍在接受戒断治疗的住院老年人中非常普遍.
- 住院治疗可以导致部分认知能力的改善,但农村的差异仍然存在.
- 同时对认知功能 (MMSE) 和肝功能障碍进行查至关重要,重点是农村干预.
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