评估CHA2DS2-VA评分和系统性炎症指数在非膜动患者:一个病例对照研究
Abdulkadir Cakmak1, Sirin Cetin2, Ercan Kahraman3
1Department of Cardiology, Faculty of Medicine, Amasya University, Amasya 05200, Türkiye.
Journal of clinical medicine
|July 12, 2025
概括
炎症标志物如NLR,PLR,SII和SIRI,当与CHA2DS2-VA得分相结合时,可以改善非膜动 (NVAF) 患者的风险预测. 这种整合有助于识别高风险个体,以制定个性化治疗策略.
科学领域:
- 心脏病学 心脏病学
- 炎症研究 炎症研究
- 生物标志物发现发现
背景情况:
- 非膜性心房动 (NVAF) 是一种常见的心律失常,与中风和死亡风险增加有关.
- 炎症在NVAF的发展和进展中起着至关重要的作用.
- 目前的风险分层工具,如CHA2DS2-VA得分,可以通过结合炎症生物标志物来增强.
研究的目的:
- 研究新型炎症指数 (NLR,PLR,SII,SIRI) 与NVAF之间的关联.
- 评估这些炎症标志物对现有的CHA2DS2-VA评分的预后附加值.
- 探索为个性化NVAF管理开发综合风险评分的潜力.
主要方法:
- 一项观察性病例控制研究,涉及330名NVAF患者和201名对照.
- 测量和比较炎症和生化参数,包括NLR,PLR,SII和SIRI.
- 应用多变量逻辑回归和接收器操作特征 (ROC) 分析来评估分数的区分能力.
主要成果:
- 与对照组相比,NVAF患者的所有炎症指数 (NLR,PLR,SII,SIRI) 在NVAF患者中显著升高 (p < 0.001).
- NLR,PLR,SII和SIRI被确定为NVAF的独立风险标志物.
- CHA2DS2-VA评分显示了与NVAF (OR = 5.55) 最强的关联,最佳截止值为≥2,提供高灵敏度和特异性.
结论:
- 炎症标志物NLR,PLR,SII和SIRI在NVAF患者中与CHA2DS2-VA得分一起使用时提供了重要的,互补的预后信息.
- 将这些炎症指数整合到临床风险评估中可以提高高风险个体的早期识别.
- 未来的研究应该专注于开发复合风险评分,如CHA2DS2-VA-炎症评分,并探索针对炎症的干预措施.
更多相关视频
相关概念视频
01:30Acute Coronary Syndrome III: Diagnostic Studies
25
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
25
01:29Assessment of the Cardiovascular System II: Inspection
419
Inspection is the initial step in assessing the cardiovascular system. It involves a detailed visual examination that provides crucial information about a patient's circulatory and cardiac health. This systematic process, conducted from head to toe, helps identify signs of cardiovascular conditions by observing physical appearance, skin and mucous membranes, jugular and carotid pulsations, chest symmetry, and the condition of the extremities.
Head and Neck
Head and Neck
419
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
123
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
123
01:27Assessment of the Cardiovascular System III: Palpation
500
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
500
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
66
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
66
01:23Assessment of the Cardiovascular System I: Subjective Data
470
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
470