十年使用Proxymetacaine化0.5%的经验,用于术后疼痛控制在表皮-离角膜交叉连接
Mohamed Gamal Elghobaier1, Issac Levy1,2,3, Mayank A Nanavaty1,4
1Sussex Eye Hospital, University Hospitals Sussex NHS Foundation Trust, Eastern Road, Brighton BN2 5BF, UK.
无防腐剂的普罗克西米塔卡因化物有效地管理了皮质脱离角膜交叉连接后的疼痛. 患者在三天后报告没有疼痛,表明一种安全有效的术后疼痛控制解决方案.
科学领域:
- 眼科医生 眼科 眼科
- 角膜外科手术 角膜外科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 角是一种渐进的眼睛疾病,需要手术干预.
- 皮质脱离角膜交叉连接 (CXL) 是一种标准的治疗方法.
- 手术后疼痛管理对于患者在CXL后的恢复至关重要.
研究的目的:
- 为了评估无防腐剂的普罗克西米塔卡因化眼滴的疗效和安全性.
- 为了评估皮质脱离角膜交叉连接 (CXL) 后的疼痛控制.
- 为了确定对角膜愈合和患者舒适性的影响.
主要方法:
- 观察性研究涉及223只眼睛的180名患有角的患者.
- 皮质脱离CXL使用无德克斯的利博弗拉和UV-A光进行.
- 在手术后,根据需要 (PRN) 给予无防腐剂的普罗克西米塔卡因化物 (0.5%),每天最多8次,持续3天.
主要成果:
- 在第一次术后访问时,在任何患者身上都没有观察到角膜愈合异常.
- 所有患者都报告说,普罗西梅他卡因药物有效控制了术后疼痛,特别是在前48小时内.
- 没有报告与使用普洛克西米他卡因化相关的并发症.
结论:
- 无防腐剂的普罗克西梅他卡因化物是一种安全有效的选择,用于在CXL上皮质脱落后管理术后的疼痛.
- 所有使用处方方案的患者在3天内完全缓解疼痛.
- 这项研究支持使用这种麻醉剂来增强患者舒适度和CXL后的康复.
更多相关视频
07:29Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
12:25Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
Published on: January 6, 2018
相关概念视频
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Mechanism of Action
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
Local Anesthetics: Pharmacokinetics
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
