客观的治疗目标及其与患者报告的炎症性肠病结果的相关性:现实世界的研究
Panu Wetwittayakhlang1, Siripoom Ngampech1, Saichol Pattarakulniyom2
1Gastroenterology and Hepatology Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai 90110, Songkhla, Thailand.
Journal of clinical medicine
|July 12, 2025
概括
患者报告的结果 (PROs) 与炎症性肠病 (IBD) 患者的临床缓解有很强的相关性,尽管与生物标志物和内镜治疗的关联是中等的. 在IBD中实现治疗目标需要全面的监测.
科学领域:
- 胃肠病学 胃肠病学
- 临床医学 临床医学
- 炎症性肠道疾病研究研究
背景情况:
- 治疗到目标的方法对于优化炎症性肠病 (IBD) 的结果至关重要.
- 关于实现客观监测目标和将患者报告的结果 (PRO) 与IBD中的这些目标相关联的现实数据有限.
研究的目的:
- 评估IBD患者客观监测目标 (临床,生物标志物,内镜) 的实现情况.
- 评估PROs与克罗恩病 (CD) 和性结肠炎 (UC) 中确定的治疗目标之间的相关性.
主要方法:
- 从2020年1月到2024年12月对112名IBD患者 (CD和UC) 的回顾性分析.
- 疾病活动通过哈维-布拉德肖指数 (HBI),部分梅奥得分,PRO2,PRO3,C反应蛋白 (CRP) 和内学得分 (SES-CD,MES) 进行评估.
- 结果在基线,1年和2年评估.
主要成果:
- 在所有时间点,UC的临床缓解率高于CD.
- 在CD和UC中,PRO2和PRO3与临床缓解有很强的相关性.
- 在CD和UC患者中观察到PROs和生物标志物/内镜缓解之间的中等相关性.
结论:
- 与CD相比,UC中更频繁地实现临床缓解.
- 在IBD中,PRO是临床缓解的可靠指标.
- 虽然PRO与临床状态保持一致,但它们与生物标志物和内镜缓解的关联是中度的,这突显了需要多方面的监测.
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