E-Gastryal® + 酸加PPI与PPI单独用于GERD:来自GENYAL®随机对照试验的结果
Cristiano Spada1,2, Daniele Salvi3, Silvia Pecere1,2
1Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
将E-Gastryal + MgAlg添加到奥梅普拉中显著减少了救援药物的使用,并改善了GERD患者的症状. 这种组合治疗提供了持续的缓解,并提高了胃食道逆流症管理的生活质量.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胃食道逆流性疾病 (GERD) 尽管使用质子抑制剂 (PPI) 治疗,但往往会出现持续的症状,影响到三分之一的患者.
- E-Gastryal + MgAlg是一种粘膜保护剂,旨在增强胃肠道屏障,防止酸性和非酸性逆流剂.
研究的目的:
- 为了评估E-Gastryal + MgAlg与奥梅普拉结合的疗效,与奥梅普拉单独治疗症状性GERD的疗效相比.
- 评估E-Gastryal + MgAlg作为GERD症状控制的维持疗法的作用.
主要方法:
- 一项随机研究涉及96名患有症状GERD和A级逆流食道炎的患者.
- 参与者接受了欧梅普拉20毫克加E-Gastryal + MgAlg或单独服用欧梅普拉20毫克.
- 主要终点是28天的救援药物使用;次要终点包括症状和生活质量得分 (RSI,GIS,GERD-HRQL,IGAP).
主要成果:
- 组合疗法组使用的救援药物显著减少 (21对40.9片,p=0.002).
- 在第4周,组合组在反流症状指数 (RSI),胃食道反流疾病影响量表 (GIS) 和GERD与健康相关的生活质量 (GERD-HRQL) 评分 (p < 0.001) 中表现出优异的改善.
- 症状缓解持续到第26周,使用E-Gastryal + MgAlg维持疗法.
结论:
- 与PPI单独治疗相比,将E-Gastryal + MgAlg与奥梅普拉结合使用为GERD患者提供了增强的症状控制.
- 这种组合疗法显示出对胃食道逆流性疾病的有效长期管理有希望.
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