孕期糖尿病和不良周产期结果:系统性审查和元分析
Dionysios Gazis1, Antigoni Tranidou1, Antonios Siargkas1
13rd Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
怀孕期间患有妊娠期糖尿病 (PGDM) 的孕妇显著增加了母亲和新生儿的风险. 这包括更高的妊娠高血压,孕前,早产和新生儿并发症,如低血糖和先天性形.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 围产儿医学 围产儿医学
背景情况:
- 全球糖尿病发病率不断上升.
- 越来越多的孕期糖尿病 (PGDM) 妇女进入怀孕.
- 确立了孕产妇高血糖症和不良周产期结局之间的联系.
研究的目的:
- 系统地审查和元分析PGDM与各种不良围产期结局之间的关联.
- 量化PGDM复杂的怀孕中这些结果的风险.
- 为了全面了解PGDM对怀孕的影响.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 包括观察性研究,比较PGDM怀孕与对照怀孕.
- 数据来源于Medline/PubMed,Scopus和Cochrane图书馆 (1999-2023年) 的数据,使用手动搜索.
- 计算了聚合的赔率比率 (OR) 和95%的置信区间 (CI).
主要成果:
- 分析了81项研究和超过1.37亿次怀孕.
- 在PGDM和19个不良周产期结果之间发现了显著的关联.
- 孕期高血压 (OR 3.16),孕前 (OR 4.46),早产 (OR 3.46),巨 (OR 2.23) 和新生儿低血糖症 (OR 19.19) 的风险增加.
- 与T2DM怀孕相比,T1DM中发现的低血糖症,死胎和围产死亡率的风险更高.
结论:
- PGDM与广泛的不良周产期结果密切相关.
- 早期检测和最佳的血糖控制至关重要.
- 综合性产前护理对于减轻PGDM怀孕的风险至关重要.
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