植物化学概况和选择性抗癌活动的Parietaria judaicaL.提取物
Izabela Bielecka1, Dorota Natorska-Chomicka2, Wioleta Dołomisiewicz1
1Department of Pharmaceutical Botany, Medical University of Lublin, 20-093 Lublin, Poland.
Molecules (Basel, Switzerland)
|July 12, 2025
概括
巴里特里亚·朱达伊卡 (Parietaria judaica) 叶片提取物显示出作为天然抗癌剂的潜力. 乙醇提取物 (PJ-E) 显示出显著的瘤选择性和对癌症细胞系的细胞毒性,需要进一步研究治疗开发.
科学领域:
- 植物化学和药理学
- 自然产品化学 自然产品化学
- 癌症生物学 癌症生物学
背景情况:
- 从自然来源寻找新型抗癌化合物的研究仍在进行中.
- 巴里埃塔利亚·朱达伊卡L. (alfavaca-de-cobra) 是一种具有潜在药用功能的植物.
- 鉴定具有针对癌细胞的选择性细胞毒性的植物衍生物质是关键的研究领域.
研究的目的:
- 为了研究Parietaria judaica叶子提取物的植物化学成分和抗癌潜力.
- 评估不同提取物的细胞毒性活动与人类癌症细胞系的小组对比.
- 为了确定提取物对癌细胞的选择性,与正常细胞相比.
主要方法:
- 用不同极性的溶剂制备了叶子提取物.
- 使用LC-ESI-MS/MS进行了植物化学分析.
- 用MTT和SRB测定对多种癌症和非癌细胞系进行了细胞毒性评估.
主要成果:
- 巴里塔利亚朱达伊卡的提取物富含多,包括酸和黄酸.
- 乙醇提取物 (PJ-E) 显示对HeLa细胞具有强烈的细胞毒性 (IC50 = 11.82 μg/mL),具有高瘤选择性 (IC50 = 139.42 μg/mL对HEK-293).
- 水提取物 (PJ-W) 对肺癌细胞具有选择性活性 (IC50 = 87.69 μg/mL),对正常细胞的毒性较低.
结论:
- 巴里特利亚朱达伊卡,特别是它的乙醇提取物,是天然抗癌化合物的有希望的来源.
- 植物提取物显示剂量依赖的抗增殖作用和瘤选择性.
- 建议进行进一步的研究,包括分离活性化合物和体内研究,以验证治疗潜力.
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