植物化学查和生物活动的Lippia多种植物 Moldenkeke
Dorcas Tlhapi1, Ntsoaki Malebo2, Idah Tichaidza Manduna1
1Centre for Applied Food Sustainability and Biotechnology, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, South Africa.
Molecules (Basel, Switzerland)
|July 12, 2025
概括
利皮亚多种植物表现出显著的抗氧化特性,特定的叶子和茎树皮提取物显示出强大的自由基清除和减少功率. 这项研究确定了为其药用贡献的关键化合物.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 利皮亚多种植物有传统的用途用于各种疾病,包括高血压和疟疾.
- 关于负责其生物活动的特定化合物的科学文献有限.
- 了解化学特征对于验证其治疗潜力至关重要.
研究的目的:
- 确定Lippia多种植物根,茎皮和叶子的化学特征.
- 评估其提取物的体外抗氧化和细胞毒性作用.
- 为了将已识别的化合物与观察到的生物活动相关联.
主要方法:
- 总和黄含量的量测量.
- 超高性能液态染色体质谱法 (UHPLC-MS) 用于化学表征.
- 在体外抗氧化剂测定 (DPPH,降低功率) 和细胞毒性测定 (MTT).
主要成果:
- 确定了20种成分,包括类,黄类和类.
- 甲醇叶提取物显示出最高的DPPH激素清除活性;茎皮提取物具有最高的降解力.
- 提取物被Vero细胞承受得很好,高达50μg/mL,在更高度时观察到一些毒性.
结论:
- 已识别的化合物如甲基素,基素, (-) - 基甲基素和6 - 生醇有助于抗氧化特性.
- 这项研究提供了Lippia多种植物部分的全面植物化学概况.
- 这些发现支持传统的治疗用途,并需要进一步研究作为一种天然疗法.
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