聚乳酸膜对特拉马多尔局部释放的表征
Lafitte Fernández-Minotre1, Mauricio Montero-Aguilar1, Febe Carolina Vázquez-Vázquez2
1Dentistry Graduate Program, Universidad de Costa Rica, San José 11501-2060, Costa Rica.
International journal of molecular sciences
|July 12, 2025
概括
使用特拉马多尔 (TMD) 开发的多乳酸 (PLA) 膜使用空气喷气旋转 (AJS). 这些药物释放膜表现出稳定的特性和良好的生物相容性,用于潜在的药物输送应用.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 聚乳酸 (PLA) 是一种可生物降解的聚合物,广泛用于生物医学应用.
- 开发有效的药物输送系统需要仔细控制药物结合和释放动力学.
- 特拉马多尔 (TMD) 是一种常见的止痛药,需要控制释放机制才能获得治疗效果.
研究的目的:
- 开发基于聚乳酸 (PLA) 的膜,使用空气喷气旋转 (AJS) 结合特拉马多尔 (TMD).
- 描述开发的PLA-TMD膜的物理化学特性并评估其生物相容性.
- 评估这些膜作为药物输送系统的潜力.
主要方法:
- 膜使用空气喷气旋转 (AJS) 用10%的PLA (控制) 和10%的PLA与TMD (80:1比率) 制造.
- 鉴定包括SEM,DSC,TGA,FT-IR和UV-VIS光谱.
- 生物相容性通过使用人类骨质母细胞通过resazurin,水晶紫色和光显微镜进行评估.
主要成果:
- SEM显示均的纤维 (<5μm) 没有空隙.
- DSC和TGA证实了统一的TMD结合及其对热性质的影响.
- 通过FT-IR验证了PLA和TMD之间的化学兼容性.
- 紫外线-VIS显示了在72小时内持续释放的TMD.
- 生物相容性测试表明没有细胞毒性作用,细胞活力与对照细胞相比较.
结论:
- 通过AJS载入TMD的PLA膜具有稳定的物理化学特性.
- 开发出来的膜与人类骨质母细胞具有良好的生物相容性.
- 这些PLA-TMD膜显示出对可控药物输送应用的前景.
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