与自我抗原的相似性 形状 皮质 识别 自免疫和传染病下的病毒
Alvaro Ras-Carmona1, Alexander Lehmann1, Pedro A Reche1
1Department of Immunology, Ophthalmology and ENT, Faculty of Medicine, University Complutense of Madrid, Pza Ramon y Cajal S/N, 28040 Madrid, Spain.
International journal of molecular sciences
|July 12, 2025
概括
分子仿真在病毒感染引发的自身免疫性疾病中起着关键作用. 这项研究发现了类似于自我抗原的病毒特异性表位,挑战T细胞自我/非自我歧视,并突出了自身免疫的风险.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 这是一种自身免疫力.
背景情况:
- 适应性免疫依赖于自我/非自我歧视来防止自身免疫反应.
- 传染病原体可以通过环境催化触发自身免疫性疾病.
- 分子仿真,即外来抗原与自身抗原相似,是自身免疫的一个拟议机制.
研究的目的:
- 调查分子模拟在关于传染病和自身免疫疾病的表位识别中的作用.
- 为了分析与人类自身抗原相似的病毒特异性表位.
- 挑战现有的T细胞自我/非自我歧视模型.
主要方法:
- 使用BLAST对人类蛋白质组进行搜索.
- 作为查询,使用了已知的病毒特异性B细胞和T细胞突变,来自人类自身免疫/传染病.
- 使用随机病毒序列 (非B/T细胞表位) 进行了对照分析.
主要成果:
- 证实了分子模拟在病毒相关自身免疫性中的重要作用.
- 确定了许多与自我抗原具有高度相似性的病毒特异性表位,特别是来自冠状病毒和病毒.
- 挑战了对T细胞自我/非自我歧视的普遍理解.
结论:
- 分子仿真是启动或延续与病毒感染相关的自身免疫的一个关键因素.
- 模仿自身抗原的病毒衍生的表位可以导致对参与细胞功能的人类蛋白质的自身免疫反应.
- 这些发现需要重新评估T细胞在自身免疫中的识别机制.
相关概念视频
Cross-reactivity
31.5K
Overview
31.5K
Antigens Involved in Adaptive Immunity
690
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
690
Immune Response Against Viral Pathogens
929
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
929
Affinity and Avidity
36.7K
Overview
36.7K
Special Features of Adaptive Immunity
1.1K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
1.1K
Diversity of Antigen Receptors
808
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
808


