非定位代谢学利用理想蛋白质概念,减轻子模型中的环境影响
Pablo Jesús Marín-García1, Jorge Mateo-López2, César Cortés-García1
1Department of Animal Production and Health, Veterinary Public Health and Food Science and Technology (PASAPTA), Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46113 Valencia, Spain.
International journal of molecular sciences
|July 12, 2025
概括
在子的饮食中限制 metionin 改变了血液代谢物,其影响因食时间而异. 识别特定的代谢物可以完善可持续动物生产的理想蛋白质概念.
科学领域:
- 动物营养 动物营养
- 代谢学 代谢学 代谢学
- 环境科学 环境科学
背景情况:
- 来自畜牧业的环境污染需要优化营养利用.
- 理想的蛋白质概念旨在将氨基酸配置文件与动物的要求相匹配,从而最大限度地减少浪费.
- 氨酸是一种关键的氨基酸,它的限制会影响动物的新陈代谢和分泌.
研究的目的:
- 为了研究成长中的子的新陈代谢变化,使用非向代谢学来研究食不同氨酸水平的食.
- 探索采样时间 (08:00对21:00) 对新陈代谢概况的影响.
- 识别潜在的生物标志物,以改进理想的蛋白质概念并减少对环境的影响.
主要方法:
- 来自生长子的血液样本的非向代谢学分析.
- 实验性饮食:Met+ (平衡氨酸) 和Met- (限制氨酸).
- 血液采样时间为8:00 (随意养) 和21:00 (10小时禁食).
- 对血尿素的有针对性的分析.
主要成果:
- 饮食和采样时间都显著调节了代谢组.
- 与21:00相比,饮食对新陈代谢的影响在08:00 (可能是由于缩) 时不那么明显.
- 伪尿素,酸,泛酸和甲酸盐被确定为潜在的生物标志物.
结论:
- 代谢分析提供了关于氨基酸限制在动物生产中的影响的见解.
- 取样时间受养模式和缩的影响,会影响新陈代谢反应.
- 准已识别的代谢物可以帮助完善理想的蛋白质概念,以提高营养效率和减少环境污染.
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