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Updated: Sep 16, 2025

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

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一个基于模块级多基因风险评分的NetWAS框架,用于识别由杏仁体介导的AD遗传模块:一项ADNI研究

Haoran Luo1,2, Shaoheng Fan1, Hongwei Liu2

  • 1Department of Computing, School of Hotel and Tourism Management, Hong Kong Polytechnic University, Hong Kong, China.

International journal of molecular sciences
|July 12, 2025
PubMed
概括

这项研究引入了一个新的框架,通过检查大脑成像特征来发现与阿尔茨海默病 (AD) 相关的遗传模块. 它揭示了杏仁体中的四个关键遗传模块,它们调解了遗传与AD进展之间的联系.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.从MCI转换为AD的转换方法阿米格达拉的桃体调解分析 调解分析在模块级别的PRS中.网络传播传播网络传播.基于网络的GWAS.

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