系统建模揭示了共享的代谢失调和ME/CFS和长期COVID的潜在治疗方法
Gong-Hua Li1, Fei-Fei Han2, Efthymios Kalafatis3
1State Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China.
International journal of molecular sciences
|July 12, 2025
概括
肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 和长期COVID共享代谢问题. 补充阿斯巴甜酸 (ASP) 或阿斯巴拉金 (ASN) 可能有所帮助,而l-ornithine和l-aspartate (LOLA) 在未来的试验中显示出希望.
科学领域:
- 代谢研究的研究.
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 和长期COVID是复杂的多系统疾病.
- 这两种疾病都有重叠的代谢症状,在诊断和治疗方面存在挑战.
- 新出现的证据表明,他们有共同的潜在代谢功能障碍.
研究的目的:
- 系统地调查ME/CFS和长期COVID患者肌肉组织中共享的代谢障碍.
- 为了确定受这些条件影响的特定代谢途径.
- 探索潜在的治疗干预措施,针对已识别的代谢不规则.
主要方法:
- 用全基因组代谢建模来分析ME/CFS患者的肌肉组织.
- 进行了in silico淘汰赛分析,以预测代谢干预的效果.
- 对长期COVID患者进行了代谢分析,重点是运动后不适 (PEM) 期间的肌肉和血液样本.
主要成果:
- ME/CFS 患者表现出氨酸和酸代谢以及氨酸和氨酸代谢途径的下调.
- 在 silico 结果表明,阿斯巴达酸盐 (ASP) 或阿斯巴拉金 (ASN) 补充可能会纠正这些缺陷.
- 长期COVID患者在PEM期间在肌肉和血液中显示出ASP显著下调.
结论:
- 共享的代谢功能障碍,特别是涉及阿斯巴酸盐,与ME/CFS和长期COVID有关.
- 作为一种潜在的治疗策略,建议补充l-ornithine和l-aspartate (LOLA).
- 需要进一步的临床试验来评估LOLA在缓解ME/CFS和长期COVID的代谢症状方面的有效性.
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