人类精子中的与年龄相关的蛋白质组变化
Mohd Amin Beg1, Abrar Osama Ismail1,2, Ayodele Alaiya3
1King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
International journal of molecular sciences
|July 12, 2025
概括
老年男性由于精子中的蛋白质变化而经历了精子生育能力的下降. 这项研究确定了与年龄相关的特定蛋白质变化,为男性生育能力下降和潜在的治疗点提供了见解.
科学领域:
- 生殖生物学和蛋白质组学
- 男人的生育能力和衰老.
- 精子动物分析分析
背景情况:
- 年龄的增长是男性不孕症的一个重要因素.
- 人类精子中与年龄相关的蛋白质组变化的理解有限.
- 精子蛋白质组的变化会影响男性的生殖健康.
研究的目的:
- 为了研究肥沃的阿拉伯男性精子中的与年龄相关的蛋白质组变化.
- 为了确定受衰老影响的特定蛋白质和途径.
- 为了解和潜在治疗与年龄相关的男性不孕症提供分子基础.
主要方法:
- 来自三个年龄组 (年轻,晚年,高级) 的梯度净化精子的LC-MS/MS分析.
- 使用Progenesis QI和UniProt/SwissProt.使用蛋白质组数据处理.
- 对差异性蛋白质表达和功能丰富的统计分析.
主要成果:
- 确定了588种蛋白质,其中93%是跨年龄组共享的.
- 发现了特定于年龄组的独特蛋白质 (MYLK4,PRSS57,HMGB4,KRT4,LPGAT1,OXCT2,MGRN1).
- 观察到与神经退行,蛋白质折叠,新陈代谢和精子运动相关的途径的显著变化.
结论:
- 衰老显著改变精子蛋白质组,影响精子生成,运动和新陈代谢.
- 与衰老相关的识别的蛋白质组签名为生育保护策略提供了一个框架.
- 分子洞察力可以指导开发疗法,以提高老年男性的精子功能.
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