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相关概念视频

Spermatogenesis01:41

Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Sperm Structure and Semen Composition01:22

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During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
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Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
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人类精子中的与年龄相关的蛋白质组变化

Mohd Amin Beg1, Abrar Osama Ismail1,2, Ayodele Alaiya3

  • 1King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

International journal of molecular sciences
|July 12, 2025
PubMed
概括

老年男性由于精子中的蛋白质变化而经历了精子生育能力的下降. 这项研究确定了与年龄相关的特定蛋白质变化,为男性生育能力下降和潜在的治疗点提供了见解.

关键词:
这是LC-MS/MS.衰老的衰老 衰老的衰老人类 人类 人类 人类 人类 人类 人类蛋白质组学 蛋白质组学精子 精子 精子

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科学领域:

  • 生殖生物学和蛋白质组学
  • 男人的生育能力和衰老.
  • 精子动物分析分析

背景情况:

  • 年龄的增长是男性不孕症的一个重要因素.
  • 人类精子中与年龄相关的蛋白质组变化的理解有限.
  • 精子蛋白质组的变化会影响男性的生殖健康.

研究的目的:

  • 为了研究肥沃的阿拉伯男性精子中的与年龄相关的蛋白质组变化.
  • 为了确定受衰老影响的特定蛋白质和途径.
  • 为了解和潜在治疗与年龄相关的男性不孕症提供分子基础.

主要方法:

  • 来自三个年龄组 (年轻,晚年,高级) 的梯度净化精子的LC-MS/MS分析.
  • 使用Progenesis QI和UniProt/SwissProt.使用蛋白质组数据处理.
  • 对差异性蛋白质表达和功能丰富的统计分析.

主要成果:

  • 确定了588种蛋白质,其中93%是跨年龄组共享的.
  • 发现了特定于年龄组的独特蛋白质 (MYLK4,PRSS57,HMGB4,KRT4,LPGAT1,OXCT2,MGRN1).
  • 观察到与神经退行,蛋白质折叠,新陈代谢和精子运动相关的途径的显著变化.

结论:

  • 衰老显著改变精子蛋白质组,影响精子生成,运动和新陈代谢.
  • 与衰老相关的识别的蛋白质组签名为生育保护策略提供了一个框架.
  • 分子洞察力可以指导开发疗法,以提高老年男性的精子功能.