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相关概念视频

ABC Transporters: Exporter01:31

ABC Transporters: Exporter

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ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains (TMDs) and nucleotide-binding domains (NBDs). The TMDs are specific to their substrates, whereas the NBDs are similar to engines that complete ATP hydrolysis to complete the substrate transport. They can be full transporters consisting of two TMDs and NBDs, half transporters with one TMD and NBD, while some encoded with a single TMD or NBD are...
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ABC Transporters: Importer01:27

ABC Transporters: Importer

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ATP-binding cassette or ABC transporters are a class of ATP-driven pumps that hydrolyze ATP to move solutes across the membrane. They can be grouped into importers and exporters. While exporters are present in all domains of life, importers exist only in bacteria and some plants.
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
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The Significance of Membrane Transport01:44

The Significance of Membrane Transport

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The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
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Membrane Transporters01:31

Membrane Transporters

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Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of all genes in the human genome code for transporters or transporter-related proteins.
Transporters are mainly composed of alpha-helices, built from bundles of ten or more helices traversing the plasma membrane. The solute-binding sites are located midway, where some of the helices are broken or distorted, making space for the binding site through...
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Carrier-Mediated Transport01:06

Carrier-Mediated Transport

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Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
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Glucose Transporters01:27

Glucose Transporters

24.2K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
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相关实验视频

Updated: Sep 16, 2025

Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development
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ABCG2传送器:从结构到功能-当前见解和开放问题

Laura Álvarez-Fernández1, Alicia Millán-García1, Gracia Merino1

  • 1Department of Biomedical Sciences-Physiology, Faculty of Veterinary Medicine, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), University of León, Campus de Vegazana s/n, 24071 León, Spain.

International journal of molecular sciences
|July 12, 2025
PubMed
概括

结合ATP的磁带输送器ABCG2对于抗药性至关重要. 本综述综合了结构生物学方面的进展,以澄清其传输机制,这对于开发新疗法至关重要.

关键词:
这就是ABCG2ABCG2.形状的变化 形状的变化结构的结构结构的结构.交通运输运输运输运输运输运输运输运输运输

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Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1
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相关实验视频

Last Updated: Sep 16, 2025

Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development
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Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1
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科学领域:

  • 结构生物学是结构生物学.
  • 分子生物学分子生物学
  • 生物化学 生物化学

背景情况:

  • ABCG2 (ATP结合盒子子子家族G成员2) 是一个关键的载体,与多药性耐药性和生理功能有关.
  • 虽然冷电子显微镜 (cryo-EM) 已经揭示了多个ABCG2结构,但高分辨率的X射线晶体结构仍然难以捉摸,阻碍了对其运输周期动态的全面理解.

研究的目的:

  • 审查最近在ABCG2结构生物学方面的进展.
  • 要突出有关ABCG2功能的持续争议和未解决的问题.
  • 建议未来整合结构和功能数据的方向,以阐明ABCG2的机制.

主要方法:

  • 编译和综合关于ABCG2结构生物学现有文献.
  • 分析冷电子显微镜 (cryo-EM) 数据,并与其他结构信息进行比较.
  • 讨论与ABCG2运输和调节相关的功能研究.

主要成果:

  • 最近的冷EM研究提供了关于ABCG2形态状态的重要见解.
  • 由于缺乏高分辨率的X射线结构,ABCG2传输周期的关键方面仍未解决.
  • 为了全面理解ABCG2.2,必须采用多学科的方法.

结论:

  • 整合各种结构和功能数据对于破译复杂的ABCG2传输机制至关重要.
  • 详细的结构洞察对于识别新型ABCG2基质和设计向抑制剂至关重要.
  • 了解ABCG2的进步为治疗开发带来了巨大的潜力,特别是在克服多种药物耐药性方面.