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Updated: Sep 16, 2025

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
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In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity

Published on: January 29, 2018

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在初级骨关节炎中,UBC9介导的SUMO途径驱动了Prohibitin-1核积累和PITX1抑制

Roxanne Doucet1,2, Abdellatif Elseoudi1,3, Bita Rostami-Afshari1,3

  • 1Viscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.

International journal of molecular sciences
|July 12, 2025
PubMed
概括

SUMOylation是一种细胞过程,通过增加核中的禁忌素 (PHB1) 来驱动骨关节炎 (OA),该禁忌素降低PITX1,这是软骨健康的关键基因. 这一发现为OA的诊断和治疗提供了新的目标.

关键词:
一个PITX1一个PITX1禁止素-1 (PHB1) 是一种这就是SUMOylation的作用.在UBC9中,UBC9是UBC9.骨关节炎是一种关节炎.

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