双极性疾病中的炎症和认知:互白素-6的分歧路径和结果
Ulises Ríos1,2, Susana Pérez1, Constanza Martínez1
1Departamento de Psiquiatría, Escuela de Medicina, Facultad de Medicina, Universidad de Valparaíso, Valparaíso 2360002, Chile.
International journal of molecular sciences
|July 12, 2025
概括
介乐-6 (IL-6) 与神经认知功能较差和双相情感障碍 (BD) 的成年人在euthymia期间更多的住院病例有关. 这种炎症标志物IL-6显著影响BD患者的认知能力和临床结果.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 双极性障碍 (BD) 与神经认知功能障碍有关,可能与炎症有关.
- 现有的研究表明,在BD情绪状态中,有关炎症生物标志物和神经认知模式的不一致的发现.
研究的目的:
- 为了研究炎症生物标志物,神经认知功能和BD在euthymia期间成年人的临床结果之间的关系.
- 为了确定特定的炎症标记是否预测神经认知表现和临床变量在euthymic BD患者.
主要方法:
- 一项涉及109名患有BD的成年患者的横截面研究.
- 测量了白血素-6 (IL-6) 和高灵敏性C反应蛋白 (hs-CRP) 的血清水平.
- 评估的神经认知参数 (ACER),自杀未遂人数 (SA) 和住院人数 (NH).
主要成果:
- 在IL-6和ACER总分,语言,视觉空间能力和方向/注意力之间发现了负相关性.
- 在IL-6和住院人数 (NH) 之间存在正相关性.
- IL-6显著预测神经认知性能 (ACER总分,语言,记忆,定向/注意力,视觉空间能力) 和NH,而hs-CRP没有显著作用.
结论:
- 介乐-6 (IL-6) 是神经认知功能和临床结果的显著预测剂,在euthymia期间患有双相情感障碍的成年人.
- 双极性障碍是理解炎症对严重精神疾病中神经认知影响的潜在模型.
- 为了充分阐明这些关系,需要在不同情绪阶段进行进一步的前性研究.
相关概念视频
Bipolar Disorder
148
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
148
Psychoneuroimmunology: Cardiovascular Disease
79
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
79
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
993
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
993
Psychological and Sociocultural Causes of Schizophrenia
192
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
192
T Cell Types and Functions
1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.4K
Negative and Cognitive Symptoms of Schizophrenia
125
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
125


