SCFA与母亲和儿童人体测量测量的关系
Małgorzata Szczuko1,2, Natalia Szabunia1, Julia Radkiewicz1
1Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.
International journal of molecular sciences
|July 12, 2025
概括
母亲肠道微生物群的代谢物,特别是短链脂肪酸 (SCFA),影响婴儿的代谢编程. 较高的SCFA水平与母亲和新生儿体重增加相关,影响婴儿健康.
科学领域:
- 微生物学 微生物学
- 代谢过程中的代谢.
- 新生儿健康 新生儿健康
背景情况:
- 短链脂肪酸 (SCFA) 在宿主新陈代谢和生理功能中起着至关重要的作用.
- 在怀孕,分娩和母乳养期间,母亲的肠道微生物群相互作用可能会影响后代的代谢编程.
- 研究母亲微生物群代谢物和婴儿发育之间的联系对于了解生命早期健康至关重要.
研究的目的:
- 探索母体人类测量和婴儿便SCFA度之间的关联.
- 为了确定婴儿出生体重,饮食和SCFA水平之间的相关性.
- 研究母体肠道微生物群代谢物在后代代谢编程中的作用.
主要方法:
- 从82名新生儿及其母亲收集便样本.
- 在婴儿便中使用气相色谱与火焰电离探测器量化SCFA.
- 统计分析以确定SCFA度,母体测量和婴儿参数之间的相关性.
主要成果:
- 婴儿SCFA水平与母亲怀孕前体重,BMI和怀孕期间体重增加之间发现了显著的相关性.
- 观察到新生儿便中的SCFA含量与婴儿出生体重和饮食 (包括母乳养) 之间的关联.
- 增加的SCFA水平与更高的母体和新生儿体重有关,分支链SCFA (BCFA) 特别与新生儿体重有关.
结论:
- 提供了母亲肠道微生物群代谢物通过SCFA影响婴儿代谢编程的间接证据.
- 证实了SCFA水平升高与母亲和新生儿体重增加之间的关联.
- 建议基于SCFA调制的母亲和婴儿健康的潜在预防和干预策略.
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