与怀孕相关的爆发性和缓慢进展的1型糖尿病
1Diabetes, Thyroid and Endocrine Center, Shin-Koga Hospital, 120 Tenjin-cho, Kurume 830-8577, Japan.
International journal of molecular sciences
|July 12, 2025
概括
怀孕相关的1型糖尿病包括 fulminant 和缓慢进展的形式. 早期诊断和及时的胰岛素治疗对于孕妇的1型糖尿病至关重要,而对那些有慢慢进展的1型糖尿病风险的人来说,监测是关键.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 1型糖尿病存在三种临床亚型:爆发性,急性发作和缓慢进展性 (成年人患潜伏性自身免疫性糖尿病).
- 在怀孕期间,可以出现爆发性和缓慢进展的1型糖尿病,称为怀孕相关的1型糖尿病.
- 爆发性1型糖尿病由于突然发病和潜在的酸性糖尿病,对母亲和胎儿构成重大风险.
研究的目的:
- 突出与怀孕相关的1型糖尿病的独特临床表现和管理策略.
- 强调早期诊断和对怀孕期间1型糖尿病发作的干预的重要性.
- 概述孕期糖尿病患者的监测方案,这些患者有患产后缓慢进展型1型糖尿病的风险.
主要方法:
- 1型糖尿病亚型的临床分类.
- 确定妊娠相关的1型糖尿病的风险因素和诊断标准.
- 对妊娠期高血糖和自身免疫性糖尿病的管理指南的审查.
主要成果:
- 孕期1型糖尿病的特征是明显的高血糖 (≥288 mg/dL) 和相对较低的HbA1c (<8.7%) 在没有糖尿病史的妇女中.
- 怀孕期糖尿病患者具有阳性反岛屿自身抗体,患产后缓慢进展型1型糖尿病的风险很高.
- 在怀孕期间怀疑患有1型糖尿病时,建议立即进行胰岛素治疗.
结论:
- 及时识别和胰岛素治疗对于管理孕妇1型糖尿病的管理至关重要.
- 缓慢进展的1型糖尿病的产后监测对于高危妊娠糖尿病患者至关重要.
- 在怀孕期间区分和管理这些1型糖尿病亚型对于孕产妇和胎儿的结果至关重要.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
3.0K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.0K
Pathophysiology of Diabetes
1.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K
Diabetes Mellitus: Overview and Type I Subtype
3.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.3K
Diabetes: Symptoms, Diagnosis, and Complications
697
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
697
Carbohydrate Metabolism
11.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.8K
Diabetes: Management and Pharmacotherapy
402
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
402


