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一个特定于患者的冠状动脉间隔液体结构相互作用模型

Elisabeth Steadman¹, Daphne Meza¹, David A Rubenstein¹

¹Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.

International journal for numerical methods in biomedical engineering

|July 12, 2025

概括

一个新的介视流体结构相互作用 (FSI) 模型揭示了冠状动脉生物力学与宏观模型相比显著的差异. 这些发现影响了内皮细胞的反应,突出了用于细胞水平分析的大规模FSI模型的局限性.

科学领域:

生物医学工程生物医学工程
计算流体动力学的流体动力学.
心血管研究研究心血管研究

背景情况:

特定于患者的冠状动脉流体结构相互作用 (FSI) 模型对于理解心血管疾病至关重要.
以前的宏观FSI模型提供了有价值的见解,但缺乏细胞水平的分辨率.

研究的目的:

开发和验证冠状动脉感兴趣区域 (ROI) 的高分辨率介视镜FSI模型.
为了比较从大尺度和宏观的FSI模型中得出的生物力学参数.
为了研究介质镜FSI模型衍生条件对内皮细胞行为的影响.

主要方法:

在COMSOL多物理中开发了一个介面镜式FSI模型,元素大小接近内皮细胞尺寸.
计算了血流诱导的剪切应力,血管壁应力和正常和狭窄冠状动脉ROI中的拉伸应力.
使用剪切拉伸装置,对人类冠状动脉内皮细胞施加计算的剪切应力和拉伸应力.
测量了内皮细胞形态和ICAM-1表达作为响应指标.

主要成果:

mesoscopic FSI 模型实现了显著改善的空间分辨率.
观测到中视镜和宏观模型之间的剪切应力和周围应力显著差异,特别是在50%的狭窄.
内皮细胞的反应 (形态学,ICAM-1表达) 受到来自 mesoscopic 模型的生物力学条件的显著影响.

结论:

与宏观模型相比,中镜式FSI模型提供了优越的局部生物力学特征.
与 mesoscopic 模型的剪切应力和应变的差异显著影响内皮细胞反应.
大规模的FSI模型可能不足以准确评估冠状动脉中细胞水平的生物力学条件.

关键词:

冠状动脉的冠状动脉内皮细胞是内皮细胞.流体结构的相互作用.剪切压力的压力.拉力应变是一种拉力应变.

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