长期夜班工作与突发性刺激性肠综合征的关联:基于人口的队列研究
Yuxin Yao1,2, Xiaojie You1,2, Shiyu Yang1,2
1Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
长期的夜班工作增加了易怒肠综合征 (IBS) 的风险. 这种关联可能是由加剧的低级炎症驱动的,特别是更长的持续时间和更高的夜班频率.
科学领域:
- 职业健康 职业健康 职业健康
- 胃肠病学 胃肠病学
- 炎症研究 炎症研究
背景情况:
- 夜班工作在全球普遍存在,影响昼夜节律和潜在的健康.
- 刺激性肠综合征 (IBS) 是一种常见的胃肠疾病,具有多因素的病因.
- 职业暴露 (如夜班) 与IBS风险之间的联系需要进一步阐明.
研究的目的:
- 调查长期夜班工作与易怒肠综合征 (IBS) 发生率之间的关联.
- 探索低级炎症在这种关系中的潜在调解作用.
- 评估夜班时间和频率对IBS风险的影响.
主要方法:
- 一个大型的英国生物库队列研究 (n=239,760) 随访至2021年12月.
- 用于量化夜班持续时间和频率的终身就业数据.
- 考克斯的比例危险模型和调解分析评估了夜班,炎症 (INFLA评分) 和IBS风险之间的关系.
主要成果:
- 与白天工作相比,夜班工作与IBS的风险明显更高.
- 在罕见/一些 (HR 1.097) 和通常/永久 (HR 1.213) 的夜班中观察到IBS风险增加.
- 夜班更长时间 (≥3年) 和更高频率 (>7班/月) 进一步增加了IBS风险 (HR分别为1.241和1.248).
- 低度炎症 (INFLA评分) 部分调解了夜班和IBS之间的关联 (3.6%的调解).
结论:
- 长期的夜班工作,以延长时间和高频率为特征,与患IBS的风险增加有关.
- 增强的低级炎症似乎是导致这种关联的重要潜在机制.
- 职业健康策略应考虑与夜班工作相关的胃肠道风险.
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