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Updated: Sep 16, 2025

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以大自然为灵感的元启发学,以优化剂量发现和计算上具有挑战性的临床试验设计

Weng Kee Wong1, Yevgen Ryeznik2, Oleksandr Sverdlov3

  • 1Department of Biostatistics, University of California, Los Angeles, CA, USA.

Clinical trials (London, England)
|July 12, 2025
PubMed
概括

这项研究探讨了用于临床试验设计的元启发学,如粒子群优化 (PSO). 将PSO应用于I/II期试验可以优化剂量发现,提高患者的安全性和估计最佳生物剂量 (OBD) 的准确性.

关键词:
延续比率模型的延续比率模型.剂量确定试验试验.最好的生物剂量是最佳的.粒子群集优化 粒子群集优化第I/II阶段试验试验

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