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Updated: Sep 16, 2025

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针对蛋白质S-化的弹头策略

Chen Zhang1, Hui Ye1, Duorui Ji1

  • 1Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, P. R. China.

Journal of the American Chemical Society
|July 12, 2025
PubMed
概括

研究人员开发了向的S-化剂 (TSNOs),以在体内修改像布鲁顿氨酸激酶 (BTK) 这样的蛋白质. 这种新的方法对癌症治疗具有前景,

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Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.
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