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Updated: Sep 16, 2025

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
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通过SMARCAL1阻断的先进癌症免疫疗法使用一种对葡萄糖敏感的CRISPR纳米疫苗

Yuwei Li1, Yuanyi Zhang2, Chenchen Li1

  • 1Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, International Joint Research Center of Human-machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|July 12, 2025
PubMed
概括

这项研究引入了一种对葡萄糖有反应的纳米疫苗,通过增强STING信号传递和抑制免疫抑制来增强癌症免疫疗法. 它通过沉默SMARCAL1有效地对抗瘤,从而产生强大的抗瘤免疫力.

关键词:
斯马卡尔1是什么意思刺痛是一种刺痛.葡萄糖反应反应的葡萄糖.免疫疗法 免疫疗法纳米疫苗的使用方法干扰素的对立功能的干扰素.

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