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相关概念视频

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

808
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Improving Translational Accuracy02:07

Improving Translational Accuracy

11.9K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

4.4K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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An integrated human immunoglobulin germline resource linking allele diversity to expressed repertoire structure.

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相关实验视频

Updated: Sep 16, 2025

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
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通过多任务深度学习增强适应性免疫受体的序列对齐.

Thomas Konstantinovsky1,2, Ayelet Peres1,2,3, Ran Eisenberg4

  • 1Department of Bioengineering, Faculty of Engineering, Bar Ilan University, 5290002 Ramat Gan, Israel.

Nucleic acids research
|July 12, 2025
PubMed
概括

新的深度学习工具AlignAIR准确地对齐免疫球蛋白序列,用于适应性免疫研究. 它改善了V(D) J重组和体质突变分析,推进了免疫遗传学和抗体工程.

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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
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Last Updated: Sep 16, 2025

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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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科学领域:

  • 免疫学 免疫学 免疫学
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 免疫球蛋白 (Ig) 序列的序列对齐对于适应性免疫受体谱系测序 (AIRR-seq) 数据分析至关重要.
  • 现有的对齐器面临V(D) J重组和体质突变 (SHM) 的挑战,这会影响对基因组分配和序列分割的准确性.

研究的目的:

  • 推出AlignAIR,一种基于深度学习的新型免疫球蛋白序列对齐器.
  • 为了克服传统对齐器在处理V(D) J重组和SHM复杂性的局限性.
  • 为了提高AIRR-seq数据分析的准确性,生产力和速度.

主要方法:

  • 开发一种包含先进模拟方法的深度学习模型.
  • 利用多任务学习框架进行综合分析.
  • 隐藏空间的整合,以捕捉体质高突变特征.

主要成果:

  • AlignAIR在等位基因分配精度,生产率,序列细分和处理速度方面取得了最先进的结果.
  • 该模型的潜在空间提供了对序列可变性和SHM模式的更深入的见解.
  • 在处理数百万个序列时证明了效率.

结论:

  • 在免疫遗传学研究和抗体工程方面,AlignAIR为免疫遗传学研究和抗体工程提供了重大进展.
  • 该工具为分析适应性免疫受体谱提供了一个关键的资源.
  • AlignAIR的设计是为了无地集成到现有的AIRR-seq管道中,具有可访问的Web和容器接口.