炎症,排泄功能障碍和精神症状之间的交叉声:尿失禁的新假设和治疗方法
Yutaka Nakagawa1, Shizuo Yamada1
1Center for Pharma-Food Research (CPFR), Graduate School of Integrative Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
概括
炎症,可能来自饮食,可能会破坏控制 incontinence的大脑网络,导致催促尿失禁. 准神经炎症可能为这种疾病提供新的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 免疫学 免疫学 免疫学
背景情况:
- 尿失禁涉及下尿道的神经复杂调节.
- 连接大脑神经网络中断与尿失禁的确切机制尚不清楚.
- 执行控制,由背侧前额叶皮层调解,对于保持禁欲至关重要.
研究的目的:
- 调查神经炎症在催促性尿失禁的发病过程中的潜在作用.
- 探索饮食引起的炎症,大脑功能和排泄功能障碍之间的联系.
- 提出一种模型,以了解冲动性尿失禁的进展情况,并确定潜在的治疗点.
主要方法:
- 该研究提出了一个基于现有数据和科学文献的假设模型.
- 它整合了神经科学,免疫学和泌尿病学的概念,以解释拟议的途径.
- 该模型将外周炎症与影响体控制的中枢神经系统变化联系起来.
主要成果:
- 促炎症饮食可能会引发下尿路炎症,增加全身细胞因子水平.
- 这些细胞因子可能会破坏血液-脑脊液屏障,导致神经炎症.
- 神经炎症可能会导致大脑区域调节膀控制,情绪反应和执行功能的功能障碍,导致冲动性尿失禁.
结论:
- 与饮食相关的炎症引发下尿路功能障碍,加上神经炎症诱导的大脑网络障碍,可能导致冲动性尿失禁的进展.
- 在下泌尿道和大脑中准抗炎和促溶解途径具有治疗潜力.
- 提出了促进抗炎和促溶解特性的新药,而不会抑制前列腺素的产生.
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