可食用的蜜蜂-亚麻油纳米结构脂质载体,以提高β-的生物可访问性:在动态消化过程中具有结构优势和受控释放
Lukai Ma1, Zijian Li2, Linjing Li2
1Key Laboratory of Green Processing and Intelligent Manufacturing of Lingnan Specialty Food of Ministry and Rural Affairs, Guangdong Provincial Key Laboratory of Lingnan Specialty Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China; College of Light Industry and Food, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Food chemistry
|July 12, 2025
概括
这项研究创建了蜜蜂-亚麻油纳米结构脂质载体 (NLC),以改善β-固醇的输送. 这些NLC显著增强了β-sitosterol.
科学领域:
- 食品科学与技术 食品科学与技术
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 植物醇β-固醇具有潜在的健康益处,但其生物可用性较差.
- 开发有效的输送系统对于增强水生物活性化合物的吸收至关重要,如β-sitosterol.
研究的目的:
- 开发和描述蜜蜂-亚麻油纳米结构脂质载体 (NLC) 用于β-固醇封装.
- 评估开发的NLCs的物理稳定性和体外消化.
- 评估NLCs对封装β-固醇生物可访问性的影响.
主要方法:
- 纳米结构脂质载体 (NLCs) 是使用可食用的蜜蜂和亚麻油制成的.
- 评估了结构分析,封装效率和物理稳定性 (pH,温度,时间).
- 实验室消化模型被用来评估β-固醇的保护和释放.
- 封装β-固醇的生物可访问性与自由β-固醇相比较.
主要成果:
- 在蜜蜂-亚麻油NLC中实现了β-的高封装效率 (92%).
- 在各种条件下,NLC在40天内表现出极好的物理稳定性.
- 试验室消化显示,增强了对胃分解的保护,并控制了β-sitosterol的肠道释放.
- 与自由形式相比,NLCs显著提高了β-醇的生物可访问性,从12.1%增加到43.9%.
结论:
- 蜂-亚麻油NLCs为封装疏水生物活性化合物提供了稳定有效的系统.
- 这种输送系统显著提高了β-固醇的生物可访问性,表明在功能性食品中的潜在应用.
- 这项研究证明了食用脂质在开发先进的纳米输送系统以改善营养吸收方面的潜力.
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