系统生物学方法研究在蓝色心脏病中线粒体功能障碍:系统性审查
Malak Elbatarny1, Yu Tong Lu2, Mostin Hu3
1Division of Cardiac Surgery, University of Toronto, 200 Elizabeth St., Toronto, ON, M5G 2C4, Canada; Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 3rd Floor, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
EBioMedicine
|July 12, 2025
概括
阴性先天性心脏病 (CCHD) 涉及线粒体功能障碍,影响细胞能量生产. 本综述强调了CCHD的系统生物学发现.
科学领域:
- 心血管生物学 心血管生物学
- 线粒体医学 线粒体医学
- 系统生物学 系统生物学
背景情况:
- 蓝色先天性心脏病 (CCHD) 影响全球数以百万计的人,往往进展到心力衰竭.
- 线粒体功能障碍是CCHD和成人心力衰竭的关键特征.
- 慢性心血管疾病诱导的色会加剧线粒体功能障碍.
研究的目的:
- 系统地审查系统生物学文献关于CCHD中线粒体功能障碍.
- 在CCHD中整合表观基因组,转录基因组和代谢基因组数据.
- 为了确定涉及到CCHD病变的分子途径.
主要方法:
- 对OVID/Medline (2010年1月至2025年6月) 的系统文献搜索.
- 包括使用非向系统生物学方法在CCHD组织或血中的研究.
- 使用功能丰富分析差异表达的基因,蛋白质和甲基化基因的分析.
主要成果:
- 31项研究产生了基因组,表观基因组,转录基因组,蛋白质基因组和代谢基因组数据.
- 确定了8种致病性SNP,73种不同甲基化的基因,4170种不同表达的基因和173种不同表达的蛋白质.
- 关键的线粒体呼吸链基因 (例如,NDUFV1,COX5A) 被涉及.
结论:
- 慢性心血管疾病的发病和进展与线粒体功能障碍有关.
- 细胞代谢,裂变和融合的改变与慢性心脏病有关.
- 系统生物学方法揭示了CCHD相关的线粒体功能障碍的分子基础.
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