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揭开肠道的塑料困境:微型和纳米塑料如何在Enchytraeus crypticus中驱动不同的毒理途径

Xing Li¹, Hao Qiu², Wenxing Li³

¹School of Geographic Sciences, East China Normal University, Shanghai 200241, China; School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou 510006, China; Institute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.

Environment international

|July 12, 2025

概括

微塑料 (MP) 和纳米塑料 (NP) 独特地改变了土壤肠. NP会导致肠道酸化和屏障损伤,而MP会破坏脂肪消化并诱导细胞衰老.

科学领域:

环境毒理学环境毒理学
生态毒理学生态毒理学
土壤生态学土壤生态学

背景情况:

肠道微环境对于宿主健康至关重要.
对微塑料 (MP) 和纳米塑料 (NP) 对肠道微环境的影响的机制理解有限.
研究土壤无脊椎动物中的塑料颗粒毒性至关重要.

研究的目的:

系统地调查Enchytraeus crypticus对MP和NP的生物和分子反应.
阐明MP和NP改变肠道微环境并引起毒性的独特机制.
了解肠道微环境变化在塑料诱导的不良影响中的作用.

主要方法:

在模拟的土壤矩阵中,暴露Enchytraeus crypticus在聚烯MPs (50微米) 和NPs (100纳米) 的环境相关度下.
对生理,病理,分子和表型变化的系统研究.
分析肠道微环境的变化,包括pH值,活性氧物种和信号通路.

主要成果:

国会议员和国民议员表现出不同的胃肠道命运,并以不同的方式重塑了肠道微环境.
NP导致肠道酸化和H2O2过度积累,激活TNF信号,并通过亡损害肠道屏障的完整性.
MPs刺激了粘液分泌,但扰乱了脂肪的消化和吸收,通过线粒体功能障碍和脂质滴积累诱导细胞衰老.

结论:

众议员和NP通过独特的分子途径在土壤无脊椎动物中诱导明显的毒理作用.
肠道微环境的改变是介导塑料毒性的关键机制.
结果提供了对MP和NP对土壤生态系统的影响差异的机制性见解.

关键词:

在AIE成像系统中,AIE成像肠道功能肠道功能脂质代谢干扰脂质代谢干扰微型和纳米塑料的微和纳米塑料

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