在加拿大安大略省进行血清检测的个体中,麻疹血清流行率
Archchun Ariyarajah1, Natasha S Crowcroft2, Kevin A Brown3
1Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Centre for Vaccine Preventable Diseases, University of Toronto, Toronto, ON, Canada; ICES, Toronto, ON, Canada.
Vaccine
|July 12, 2025
概括
在安大略省,麻疹血清流行率低于群体免疫水平,特别是在青少年和年轻人中. 这表明,由于特定人群的免疫缺陷,维持麻疹消除存在潜在挑战.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 加拿大在1998年实现了麻疹消除.
- 疫苗覆盖率低于最佳水平和进口病例造成了持续的疫情爆发风险.
- 由于疫苗覆盖率数据的局限性,需要进行血清流行研究.
研究的目的:
- 在加拿大安大略省测量麻疹血清流行率.
- 评估人口对麻疹的免疫力.
- 为了确定影响麻疹免疫力的社会人口学因素.
主要方法:
- 从349,451个人的麻疹IgG血清学数据 (2014-2016) 进行了链接.
- 使用一个横截面设计.
- 估计的血清流行总体和社会人口统计因素.
主要成果:
- 血清流行率为83.5% (≥275mIU/mL),低于90-95%的群体免疫门.
- 在青少年 (75.3%) 和年轻成年人 (75.8%) 中观察到的血清流行率最低.
- 1985年以后出生的移民的血清流行率较低 (71.0%),相比于加拿大出生的个人 (77.8%).
结论:
- 对血清流行率数据的解释因麻疹保护相关的不确定性而复杂.
- 根据年龄和移民身份观察到麻疹血清流行率的显著差异.
- 青少年,年轻人和年轻移民的免疫缺陷可能会挑战安大略省持续消除麻疹.
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