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Updated: Sep 15, 2025

Author Spotlight: Developing Novel Anticancer Therapeutics Targeting the DNA Damage Response
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Author Spotlight: Developing Novel Anticancer Therapeutics Targeting the DNA Damage Response

Published on: June 14, 2024

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修复DNA不匹配的蛋白质MSH6是一种PD-L1表达的新型调节剂

Kirsten Brooksbank1, Charlotte Smith1, Eleni Maniati2

  • 1Centre for Cancer Cell & Molecular Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

Neoplasia (New York, N.Y.)
|July 12, 2025
PubMed
概括

丢失的DNA修复基因MLH1,MSH2和PMS2在癌症中增加PD-L1,但MSH6的损失不是由于MSH6.

关键词:
免疫治疗是一种免疫疗法.在MSH6中,MSH6是MSH6.纠正不匹配的修复方法在PD-L1中.转录因子是一种转录因子.

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