压力腹内喷雾化疗 (PIPAC) 对于腹恶性瘤,对其职业安全的系统审查
Eoghan Burke1, Patricia Harkins2, Sarah Fenn1
1Department of Surgery, The Mater Misericordiae University Hospital Eccles Street, Phibsborough, Dublin 7, Ireland.
概括
压缩腹膜内气溶化疗 (PIPAC) 对医疗保健工作者来说是安全的. 职业安全监测显示,在使用安全措施时,在PIPAC程序期间没有显著的暴露风险.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 职业健康 职业健康 职业健康
背景情况:
- 压缩性腹膜内气溶化疗 (PIPAC) 是一种创新的方法,用于为腹膜恶性瘤提供化疗.
- 在药物分发和组织透方面,PIPAC比高热性腹膜内化学疗法 (HIPEC) 具有潜在的优势.
- 人们对PIPAC中的气溶细胞毒剂对工作人员的职业健康风险存在担忧.
研究的目的:
- 系统地审查和评估PIPAC程序对医疗保健人员的职业安全.
- 评估PIPAC期间外科和外科周围人员的潜在暴露风险.
主要方法:
- 在PubMed,EMBASE和Web of Science进行了系统的文献搜索.
- 包括9个前性欧洲研究 (2013-2021),涉及24个PIPAC程序.
- 通过环境空气采样,表面擦拭试验和生物监测 (尿液/血) 来评估职业暴露.
主要成果:
- 空气污染水平始终无法检测或低于安全值.
- 生物监测表明,卫生保健工作者没有可测量的全身暴露.
- 表面污染是最小的,主要是在手套和设备上,并且低于HIPEC中通常看到的.
结论:
- 当与适当的安全预防措施一起实施PIPAC程序时,对医疗保健人员的职业风险是最小的.
- 这些发现支持PIPAC在临床环境中对医疗保健工作者暴露的安全使用.
- 进一步的研究可能将重点放在长期职业健康结果和完善安全协议上.
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